Triple Point Biologics' Serine Proteinase Inhibitors antibody catalog covers the SERPIN superfamily — a structurally conserved class of serine protease inhibitors defined by a shared ~380-residue serpin domain and a reactive center loop (RCL) that acts as a pseudosubstrate for target proteases. The superfamily is organized into clades (SERPINA through SERPINH and beyond), with members including SERPINA1 (α1-antitrypsin), SERPINB family intracellular inhibitors, SERPINC1 (antithrombin), SERPINE1 (PAI-1), SERPING1 (C1-inhibitor), and SERPINH1 (HSP47). Collectively, these proteins regulate serine proteases across the coagulation cascade, fibrinolytic system, complement pathway, and extracellular matrix remodeling, making them central research targets in plasma protein biology, thrombosis, and inflammatory signaling.

TPB has produced rabbit polyclonal antibodies against SERPIN family members since 1994, with immunogens raised against recombinant or peptide antigens mapped to functionally characterized domains — including the RCL, the shutter region, and hinge residues implicated in conformational change. Each antibody in this catalog has been validated for Western blot (WB) under denaturing conditions and immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue; selected clones have additionally been Cross-reactivity with human, mouse, and rat orthologs is reported as validated or predicted based on sequence identity at the epitope region, not assumed. Every antibody target in this collection has a corresponding recombinant protein produced in the same laboratory, enabling consistent use of matched positive controls across experimental runs. See our quality and validation standards for full documentation of lot-to-lot testing criteria.

Research applications supported by this antibody panel include quantification of SERPINC1 and SERPINE1 in anticoagulation and fibrinolysis studies, detection of SERPING1 in complement pathway experiments, and profiling of SERPINH1 as a collagen-specific chaperone in fibrosis models. For experimental design guidance, refer to our protease activity assays guide, the protease inhibitor screening protocol, and recommendations for using recombinant protein positive controls. Matched recombinant proteins for all targets listed here are available through the TPB recombinant protein catalog.