Monthly Archives: June 2026

Standard polyclonals have a sensitivity advantage — they bind many epitopes on the same target, so even if one epitope is masked or modified, signal still appears. But that sensitivity comes at a cost: every new bleed delivers a slightly different population of antibodies.

BACE1 is a type-I transmembrane aspartic proteinase with three biologically meaningful regions: the catalytic ectodomain, the stalk near the membrane, and the cytoplasmic C-terminal tail. Each domain answers a different question.

Every datasheet recommends a starting dilution, but the dilution that works in our hands isn’t always the dilution that works in yours. Here’s how we recommend titrating.